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2019 (v.27 no.2)

Translational and Clinical Pharmacology

Korean Society for Clinical Pharmacology and Therapeutics
Quarter
ISSN: 2289-0882

  • PKconverter: R package to convert the pharmacokinetic parameters

    Hyeseon Cho, Eun-Kyung Lee

    TCP | v.27, no.2, pp.73-79, Jun, 2019

    Abstract

    Population pharmacokinetic analysis and modeling procedures typically require estimates of both population and individual pharmacokinetic parameters. However, only some of these parameters are contained in models and only parameters in the model can be estimated. In this paper, we introduce a new R package, PKconverter, to calculate pharmacokinetic parameters using the relationships among them. After fitting the model, other parameters can be calculated from the functional relationship among the parameters. PKconverter provides the functions to calculate whole parameters along with a Shiny application for converting the parameters. With this package, it is also possible to calculate the standard errors of the other parameters that are not in the model and estimate individual parameters simultaneously.

    Keyword

    Pharmacokinetic model, Pharmacokinetic parameter, Population analysis, R, Shiny