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2018 (v.26 no.3)

Translational and Clinical Pharmacology

Korean Society for Clinical Pharmacology and Therapeutics
Quarter
ISSN: 2289-0882

  • Microbe-derived extracellular vesicles as a smart drug delivery system

    Jinho Yang, Eun Kyoung Kim, Andrea McDowell, Yoon-Keun Kim

    TCP | v.26, no.3, pp.103-110, Sep, 2018

    Abstract

    The human microbiome is known to play an essential role in influencing host health. Extracellular
    vesicles (EVs) have also been reported to act on a variety of signaling pathways, distally transport
    cellular components such as proteins, lipids, and nucleic acid, and have immunomodulatory effects.
    Here we shall review the current understanding of the intersectionality of the human microbiome
    and EVs in the emerging field of microbiota-derived EVs and their pharmacological potential. Microbes
    secrete several classes of EVs: outer membrane vesicles (OMVs), membrane vesicles (MVs),
    and apoptotic bodies. EV biogenesis is unique to each cell and regulated by sophisticated signaling
    pathways. EVs are primarily composed of lipids, proteins, nucleic acids, and recent evidence suggests
    they may also carry metabolites. These components interact with host cells and control various
    cellular processes by transferring their constituents. The pharmacological potential of microbiomederived
    EVs as vaccine candidates, biomarkers, and a smart drug delivery system is a promising
    area of future research. Therefore, it is necessary to elucidate in detail the mechanisms of microbiome-
    derived EV action in host health in a multi-disciplinary manner.

    Keyword

    Drug delivery system, Extracellular vesicles, Microbiome, Pharmabiotics