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2017 (v.25 no.3)

Translational and Clinical Pharmacology

Korean Society for Clinical Pharmacology and Therapeutics
Quarter
ISSN: 2289-0882

  • Intracerebroventricular drug administration

    Arthur J. Atkinson, Jr.

    TCP | v.25, no.3, pp.117-124, Sep, 2017

    Abstract

    Among the various routes of drug administration, perhaps the least studied is intracerebroventricular (ICV) administration.  This route has been shown to be particularly useful in administering to the central nervous system (CNS) drugs that do not cross the blood-brain barrier readily.  As such, the ICV route is a valuable option for providing therapeutic CNS drug concentrations to treat patients with CNS infectious and neoplastic diseases.  This route of drug administration also has the advantage of  minimizing systemic toxicity.

    Keyword

    Intracerebroventricular drug administration, Cerebrospinal fluid physiology, Pharmacokinetics, Meningitis, CNS cancer