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2018 (v.26 no.2)

Translational and Clinical Pharmacology

Korean Society for Clinical Pharmacology and Therapeutics
ISSN: 2289-0882

  • Pharmacodynamic principles and the time course of delayed and cumulative drug effects

    Nick Holford

    TCP | v.26, no.2, pp.56-59, Jun, 2018


    This tutorial reviews the principles of the concentration - effect relationship for the usual case when drug effects are delayed relative to changes in circulating concentrations. The key processes determining delay are distribution from the circulation to the receptor, binding to the receptor to produce a stimulus and translation of the receptor stimulus into an effect through turnover of physiological mediators. Some clinical outcomes are dependent on the accumulation of drug action which is predictable in terms of basic pharmacokinetic and pharmacodynamic concepts.


    Cumulative response, Delayed of drug effect, Receptor binding, Turnover models