2017 (v.25 no.2)
Translational and Clinical Pharmacology
Korean Society for Clinical Pharmacology and Therapeutics
Parameter estimation for sigmoid Emax models in exposure-response relationship
TCP | v.25, no.2, pp.74-84, Jun, 2017
The purpose of this simulation study is to explore the limitation of the population PK/PD analysis using data from a clinical study and to help to construct an appropriate PK/PD design that enable precise and unbiased estimation of both fixed and random PD parameters in PK/PD analysis under different doses and Hill coefficients. Seven escalating doses of virtual drugs with equal potency and efficacy but with five different Hill coefficients were used in simulations of single and multiple dose scenarios with dense sampling design. A total of 70 scenarios with 100 subjects were simulated and estimated 100 times applying 1-compartment PK model and sigmoid Emax model. The bias and precision of the parameter estimates in each scenario were assessed using relative bias and relative root mean square error. For the single dose scenarios, most PD parameters of sigmoid Emax model were accurately and precisely estimated when the Cmax was more than 85% of EC50, except for typical value and inter-individual variability of EC50 which were poorly estimated at low Hill coefficients. For the multiple dose studies, the parameter estimation performance was not good. This simulation study demonstrated the effect of the relative range of sampled concentrations to EC50 and sigmoidicity on the parameter estimation performance using dense sampling design.
pharmacodynamic parameter estimation, exposure-response relationship, PK/PD modeling and simulation, stochastic simulation and estimation, sigmoid Emax Model