2001 (v.9 no.2)
The Journal of Korean Society for Clinical Pharmacology and Therapeutics
Korean Society for Clinical Pharmacology and Therapeutics
Effects of Sildenafil Citrate on Autonomic Nervous System in Normal Young Man
J Korean Soc Clin Pharmacol Ther | v.9, no.2, pp.137-143, Dec, 2001
Background: Sildenafil citrate (Viagra(R)) improves sexual functions in men with erectile dysfunction and is widely prescribed. But little is known about the effects of sildenafil citrate on autonomic nervous system.
Methods : Seventeen health male subjects (age 26-36 years) were investigated. Blood pressure (BP), heart rate(HR), and autonomic nervous function tests, such as BP rise in the sustained hand-grip, sympathetic skin reflex(SSR), HR variation with deep breathing(HR variation), and Valsalva ratio, were measured before and 60 minutes after administration of a single 50mg oral dose of sildenafil citrate.
Results : Systolic BP were slightly decreased after sildenafil citrate administration (118.8±11.77 mmHg → 112.7±13.8 mmHg, p = 0.048). HR and diastolic BP were not changed significantly after sildenafil citrate administration. And autonomic nervous function tests were not changed significantly after sildenafil citrate.
Conclusions : Sildenafil citrate does not cause significant changes in autonomic nervous system except systolic BP.