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2001 (v.9 no.2)

The Journal of Korean Society for Clinical Pharmacology and Therapeutics

Korean Society for Clinical Pharmacology and Therapeutics
ISSN: 1225-5467

  • Effects of Sildenafil Citrate on Autonomic Nervous System in Normal Young Man

    Park, Moon-Ho, Koh, Seong-Beom, Kim, Byung-Jo, Park, Kun-Woo, Lee, Dae-Hie

    J Korean Soc Clin Pharmacol Ther | v.9, no.2, pp.137-143, Dec, 2001


    Background: Sildenafil citrate (Viagra(R)) improves sexual functions in men with erectile dysfunction and is widely prescribed. But little is known about the effects of sildenafil citrate on autonomic nervous system.

    Methods : Seventeen health male subjects (age 26-36 years) were investigated. Blood pressure (BP), heart rate(HR), and autonomic nervous function tests, such as BP rise in the sustained hand-grip, sympathetic skin reflex(SSR), HR variation with deep breathing(HR variation), and Valsalva ratio, were measured before and 60 minutes after administration of a single 50mg oral dose of sildenafil citrate. 

    Results : Systolic BP were slightly decreased after sildenafil citrate administration (118.8±11.77 mmHg → 112.7±13.8 mmHg, p = 0.048). HR and diastolic BP were not changed significantly after sildenafil citrate administration. And autonomic nervous function tests were not changed significantly after sildenafil citrate.

    Conclusions : Sildenafil citrate does not cause significant changes in autonomic nervous system except systolic BP.


    Sildenafil citrate, Autonomic nervous system, Blood pressure